Models of Inflammation: Carrageenan? or Complete Freund's Adjuvant (CFA)–Induced Edema and Hypersensitivity in the Rat

Animal models of inflammation are used to assess the production inflammatory mediators at sites inflammation, processing pain sensation CNS sites, anti-inflammatory properties agents such as nonsteroidal drugs (NSAIDs), and efficacy putative analgesic compounds in reversing cutaneous hypersensitivity. Detailed this article methods elicit measure carrageenan- complete Freund's adjuvant (CFA)–induced inflammation. Due possible differences between dorsal root sensory system trigeminal system, injections into either footpad or vibrissal pad described. In manner, can be assessed tissue innervated by lumbar ganglion neurons (footpad) (vibrissal pad). © 2021 Wiley Periodicals LLC.